کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5561008 | 1562076 | 2017 | 9 صفحه PDF | دانلود رایگان |
- Review established mechanisms of anesthesia-induced developmental neurotoxicity
- Introduce a holistic approach that evaluates both neuronal and non-neuronal causes
- Incorporate literature from related fields to speculate on possible new mechanisms
- Generate hypotheses to guide future research into anesthesia-induced neurotoxicity
The year 2016 marked the 15th anniversary since anesthesia-induced developmental neurotoxicity and its resulting cognitive dysfunction were first described. Since that time, multiple scientific studies have supported these original findings and investigated possible mechanisms behind anesthesia-induced neurotoxicity. This paper reviews the existing mechanistic literature on anesthesia-induced neurotoxicity in the context of a holistic approach that emphasizes the importance of both neuronal and non-neuronal cells during early postnatal development. Sections are divided into key stages in early neural development; apoptosis, neurogenesis, migration, differentiation, synaptogenesis, gliogenesis, myelination and blood brain barrier/cerebrovasculature. In addition, the authors combine the established literature in the field of anesthesia-induced neurotoxicity with literature from other related scientific fields to speculate on the potential role of non-neuronal cells and to generate new future hypotheses for understanding anesthetic toxicity and its application to the practice of pediatric anesthesia.
Journal: Neurotoxicology and Teratology - Volume 60, MarchâApril 2017, Pages 24-32