کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561008 1562076 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A holistic approach to anesthesia-induced neurotoxicity and its implications for future mechanistic studies
ترجمه فارسی عنوان
یک رویکرد جامع به عصبی نوظهور ناشی از بیهوشی و پیامدهای آن برای مطالعات مکانیزه آینده
کلمات کلیدی
بی حسی ناشی از عصبی، بیهوشی کودکان، توسعه عصبی، نوزاد علوم پایه، کارازمایی بالینی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Review established mechanisms of anesthesia-induced developmental neurotoxicity
- Introduce a holistic approach that evaluates both neuronal and non-neuronal causes
- Incorporate literature from related fields to speculate on possible new mechanisms
- Generate hypotheses to guide future research into anesthesia-induced neurotoxicity

The year 2016 marked the 15th anniversary since anesthesia-induced developmental neurotoxicity and its resulting cognitive dysfunction were first described. Since that time, multiple scientific studies have supported these original findings and investigated possible mechanisms behind anesthesia-induced neurotoxicity. This paper reviews the existing mechanistic literature on anesthesia-induced neurotoxicity in the context of a holistic approach that emphasizes the importance of both neuronal and non-neuronal cells during early postnatal development. Sections are divided into key stages in early neural development; apoptosis, neurogenesis, migration, differentiation, synaptogenesis, gliogenesis, myelination and blood brain barrier/cerebrovasculature. In addition, the authors combine the established literature in the field of anesthesia-induced neurotoxicity with literature from other related scientific fields to speculate on the potential role of non-neuronal cells and to generate new future hypotheses for understanding anesthetic toxicity and its application to the practice of pediatric anesthesia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurotoxicology and Teratology - Volume 60, March–April 2017, Pages 24-32
نویسندگان
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