کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5561964 1562303 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNAs as key mediators of hepatic detoxification
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
MicroRNAs as key mediators of hepatic detoxification
چکیده انگلیسی

MicroRNAs (miRNAs) are a class of short noncoding RNAs that modulate gene expression at both transcriptional and post-transcriptional levels. Many studies have extensively revealed the significance of miRNAs in mediating liver development and diseases. However, their role in hepatic detoxification processes has been explored only recently. In this review, we summarized the up-to-date knowledge about miRNA dependent regulation of enzymes involved in all three phases of the drugs and xenobiotics detoxification process. We also discussed the role of miRNA in regulating some upstream nuclear receptors involving gene expression of enzymes for detoxification process in liver. The toxicological significance of miRNAs in liver diseases and future research perspectives are finally presented.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volumes 368–369, 10 August 2016, Pages 80-90
نویسندگان
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