کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5566168 1563439 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Methodologic considerations of household-level methicillin-resistant Staphylococcus aureus decolonization among persons living with HIV
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Methodologic considerations of household-level methicillin-resistant Staphylococcus aureus decolonization among persons living with HIV
چکیده انگلیسی


- Simultaneous treatment of household members may reduce MRSA decolonization failure.
- Pragmatic challenges limit the ability to conduct household-level research in persons living with HIV.
- Ensuring confidentiality of HIV status must be a priority in household-level interventions.

BackgroundPeople living with HIV (PLWH) have a higher prevalence of methicillin-resistant Staphylococcus aureus (MRSA) colonization and likelihood of recurrent infection than the general population. Simultaneously treating MRSA-colonized household members may improve success with MRSA decolonization strategies. This article describes a pilot trial testing household-level MRSA decolonization and documents methodologic and pragmatic challenges of this approach.MethodsWe conducted a randomized controlled trial of individual versus individual-plus-household MRSA decolonization to reduce recurrent MRSA. PLWH with a history of MRSA who are patients of an urban HIV clinic received a standard MRSA decolonization regimen. MRSA colonization at 6 months was the primary outcome.ResultsOne hundred sixty-six patients were referred for MRSA screening; 77 (46%) enrolled. Of those, 28 (36%) were colonized with MRSA and identified risk factors consistent with the published literature. Eighteen were randomized and 13 households completed the study.ConclusionsThis is the first study to report on a household-level MRSA decolonization among PLWH. Challenges included provider referral, HIV stigma, confidentiality concerns over enrolling households, and dynamic living situations. Although simultaneous household MRSA decolonization may reduce recolonization, recruitment and retention challenges specific to PLWH limit the ability to conduct household-level research. Efforts to minimize these barriers are needed to inform evidence-based practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Infection Control - Volume 45, Issue 10, 1 October 2017, Pages 1074-1080
نویسندگان
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