Aronia juice suppresses the elevation of postprandial blood glucose levels in adult healthy Japanese

Aronia has various functions toward human health, including the beneficial effect on hypertension, hyperglycemia and hyperlipidemia. Recently, we identified cyanidin-3,5-O-diglucoside as DPP IV inhibitor from Aronia juice. We also found its beneficial effect on hyperglycemia in KKAy mice fed aronia juice. In this study, to examine the effect of aronia juice on postprandial blood glucose levels in Japanese, we performed an oral meal tolerance test (OMTT). We found that postprandial blood glucose levels were reduced in aronia juice-administered adult healthy Japanese. We also found that there was no difference of reduction levels of postprandial blood glucose between male and female. We also found that activities of dipeptidyl peptidase IV (DPP IV), α-glucosidase and angiotensin-converting enzyme (ACE) were reduced by aronia juice. These results suggest that aronia juice suppresses the elevation of postprandial blood glucose levels through inhibition of these enzyme activities and may be useful for prevention of metabolic diseases in adult healthy Japanese.