کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5580879 1404188 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer
ترجمه فارسی عنوان
شناسایی و پیامدهای بالینی سلولهای بنیادی سرطان در سرطان کولورکتال
کلمات کلیدی
سرطان، کارسینوما نشانگرها، سلول بنیادی، درمان،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
چکیده انگلیسی
Cancer stem cells (CSCs) are cancer cells that are responsible for initiation, progression, metastasis, and recurrence in cancer. The aim of this review was to analyze the markers for identifying of CSCs in colorectal carcinoma, as well as the prognostic and therapeutic implications of these markers in the cancer. CSCs are insensitive to the current drug regimens. In colorectal carcinoma, markers, including Nanog, Oct-4, SOX-2, Lgr-5, CD133, CD24, CD29, ALDH1, EpCAM, CD44, CD166, and CD26, are commonly used for the identification and isolation of CSCs. In addition, ALDH1, CD24, CD44, CD133, CD166, EpCAM, Lgr-5, Nanog, and SOX-2 could have clinical roles in predicting pathological stages, cancer recurrence, therapy resistance, and patients' survival in patients with colorectal carcinoma. In light of the current knowledge of CSCs in colorectal carcinoma, novel potential therapeutic strategies, such as development of monoclonal antibodies or immunotoxins and targeting various cell surface molecules in colorectal CSCs and/or components of signaling pathways, have been developed. This could open new opportunities for the better management of patients with colorectal carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Colorectal Cancer - Volume 16, Issue 2, June 2017, Pages 93-102
نویسندگان
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