MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study

This is the first study evaluating the FCN2 gene polymorphisms in patients with RF and rheumatic carditis finding a protective effect of −986 GG and −4 GG genotypes in the development of RF and the −4 AG genotype for the development of carditis. Our data do not support a possible role for MBL2 polymorphisms in the pathogenesis and in the clinical manifestations of RF.