کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5584896 | 1567994 | 2017 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effects of Ïâ6 and Ïâ3 fatty-acids on early stages of mice DMBA submandibular glands tumorigenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
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چکیده انگلیسی
The aim of this work was: to assess the impact of diets enriched in polyunsaturated fatty acids Ïâ3 and Ïâ6 families on the lipid profile of cell membrane and their effect on cycle regulation and apoptosis, evaluated by TP53 and Ki-67 expression in 9,10-dimethyl-1,2-benzanthracene (DMBA) induced tumor development in submandibular glands (SMG) in murine models. To generate tumorigenic changes, SMG mice in the experimental group were injected with 50 μl of 0.5% of DMBA. Both control (no DMBA) and experimental groups of BALB/c mice were fed with: chia oil (ChO), rich in Ïâ3 fatty acid; corn oil (CO), rich in Ïâ6/Ïâ3 fatty acid; and safflower (SO) oil, rich in Ïâ6fatty acid. Results demonstrate novel differential effects of Ïâ3 and Ïâ6 PUFAs on the regulation of early tumorigenesis events in murine SMG injected with DMBA. This knowledge may help to develop chemoprotective treatments, therapeutic agents and health promotion and prevention activities in humans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 125, October 2017, Pages 48-55
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 125, October 2017, Pages 48-55
نویسندگان
M.E. Scherma, G. Madzzuduli, R.A. Silva, M.I. Garay, G. Repossi, M. Brunotto, M.E. Pasqualini,