Full Length ArticleSerum sclerostin decreases following 12Â months of resistance- or jump-training in men with low bone mass

- Serum sclerostin decreased after 12 months of resistance training or jump training that increased whole body and lumbar spine BMD.
- Serum IGF-I increased significantly after 12 months of resistance training or jump training.
- Serum PTH did not change after 12 months of resistance training or jump training

PurposeWe previously reported that 12 months of resistance training (RT, 2 ×/wk, N = 19) or jump training (JUMP, 3 ×/wk, N = 19) increased whole body and lumbar spine BMD and increased serum bone formation markers relative to resorption in physically active (≥ 4 h/wk) men (mean age: 44 ± 2 y; median: 44 y) with osteopenia of the hip or spine. The purpose of this secondary analysis was to examine the effects of the RT or JUMP intervention on potential endocrine mediators of the exercise effects on bone, specifically IGF-I, PTH and sclerostin.MethodsFasting blood samples were collected after a 24-h period of no exercise at baseline and after 12 months of RT or JUMP. IGF-I, PTH and sclerostin were measured in serum by ELISA. The effects of RT or JUMP on IGF-I, PTH and sclerostin were evaluated using 2 × 2 repeated measures ANOVA (time, group). This study was conducted in accordance with the Declaration of Helsinki and was approved by the University of Missouri IRB.ResultsSclerostin concentrations in serum significantly decreased and IGF-I significantly increased after 12 months of RT or JUMP; while PTH remained unchanged.ConclusionThe beneficial effects of long-term, progressive-intensity RT or JUMP on BMD in moderately active men with low bone mass are associated with decreased sclerostin and increased IGF-I.