کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5586628 1568660 2017 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemotherapy and tyrosine-kinase inhibitors for medullary thyroid cancer
ترجمه فارسی عنوان
مهارکننده های شیمی درمانی و تیروزین کیناز برای سرطان مدولاری تیروئید
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Cytotoxic chemotherapy can control tumor burden in some patients with response rates of around 20% in old series. For the last 10 years, systemic therapy for MTC patients with large tumor burden and documented progression of the disease has involved the use of tyrosine kinase inhibitors targeting VEGFR and ret. Progression-free survival benefits have been demonstrated for both vandetanib and cabozantinib, as compared to placebo. Although these molecules are effective, they also have specific toxicity profiles which require a thorough clinical management in specialized centers. In the present review, we describe the work-up and treatment modalities of patients with advanced or metastatic medullary thyroid cancer with a focus on chemotherapy and targeted therapy results.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 31, Issue 3, June 2017, Pages 335-347
نویسندگان
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