کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5587128 | 1568787 | 2017 | 8 صفحه PDF | دانلود رایگان |
- The median time for developing diabetes in women with a history of GDM is 6.95Â years.
- The total cumulative incidence rate of diagnosed diabetes at the median follow-up time of approximately 12Â years was 9/1000 in women with GDM.
- BMI and family history of type 2 diabetes are major predisposing factors for future risk of diabetes in women with prior GDM.
AimVery few extensive follow-up investigations evaluating patients with history of gestational diabetes mellitus (GDM) have been documented. We conducted this longitudinal study to estimate the incidence of diabetes and its predictors in women with and without GDM.MethodA total of 2458 eligible women, aged 20-50Â years (476 with GDM and 1982 without GDM) were selected from among participants of the Tehran Lipid and Glucose study, based on the World Health Organization definition for GDM screening. Pooled logistic regression was used to assess the association between time-dependent covariates and diabetes.ResultsThe incidence rate of diagnosed diabetes was 9/1000 for women with GDM and 4/1000 for their counterparts, without GDM. Kaplan-Meier curve indicated a significantly shorter median time for developing diabetes in women with a history of GDM (6.95Â years [IQ: 4.22-10.71]), compared to their healthy peers (8.45Â years [IQ: 5.08-10.89]). BMI and previous family history of diabetes were found as major risk factors for future diabetes in women with GDM.ConclusionThe results presented here lead to better identification and selection of at-risk women with prior GDM history.
Journal: Diabetes Research and Clinical Practice - Volume 128, June 2017, Pages 24-31