کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5587762 1568861 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolution of specificity in cartilaginous fish glycoprotein hormones and receptors
ترجمه فارسی عنوان
تکامل خاصیت هورمون ها و گیرنده های گلیکوپروتئین ماهی غضبی
کلمات کلیدی
هورمون گلیکوپروتئین، گیرنده گلیکوپروتئین، هورمون تحریک کننده تیروئید، هورمون تحریک کننده فولیکول، هورمون لووتینیزه، سیر تکاملی، فیلوژنی کوسه فیل،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی
Glycoprotein hormones (GpH) interact very specifically with their receptors to mediate hypothalamic-pituitary-peripheral gland endocrine signaling. Vertebrates typically have three functionally distinct GpH endocrine signaling complexes: follicle-stimulating hormone, luteinizing hormone, and thyroid-stimulating hormone, and their receptors. Each hormone consists of a common α subunit bound to one of three different β subunits. Individual hormone subunits and receptors are present in genomes of early metazoans, and a subset of hormone subunits and receptors has been recently characterized in sea lamprey. However, it remains unclear when the full complement of hormone and receptor protein families first appeared, and when specificity of interactions between GpH hormones and receptors first evolved. Here we present phylogenetic analyses showing that the elephant shark (Callorhinchus milii) genome contains sequences representing the current diversity of all hormone subunits and receptors in these co-evolving protein families. We examined specificity of hormone and receptor interactions using functional assays testing reporter gene activation by elephant shark follicle-stimulating hormone, luteinizing hormone, and thyroid-stimulating hormone receptors. We show highly specific, dose-responsive hormone interactions for all three complexes. Our results suggest that co-evolution of specificity between proteins in these endocrine signaling complexes occurred prior to the divergence of Chondrichthyes from the chordate lineage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: General and Comparative Endocrinology - Volume 246, 15 May 2017, Pages 309-320
نویسندگان
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