کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589241 | 1569810 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis
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کلمات کلیدی
CNVPCNAMTUS1ATIPangiotensin II receptor type 2AT2ESCCERKFFPE - MEPProliferating Cell Nuclear Antigen - آنتیژن هسته ای تکثیر سلولیAngiotensin II - آنژیوتانسین دوloss of heterozygosity - از دست دادن هتروزیگوتیسمAng II - دومCancer - سرطانformalin fixed paraffin embedded - فرمالین ثابت پارافین تعبیه شده استLOH - لوهانSystemic lupus erythematosus - لوپوس اریتماتوی سیستمیکSLE - لوپوس منتشر یا لوپوس اریتماتوس سیستمیکknock-out - ناک اوتCopy number variant - نسخه شماره نسخه را کپی کنیدTumor suppressor gene - ژن سرکوب کننده تومورOral tongue squamous cell carcinoma - کارسینوم سلول سنگفرشی زبان دهانیEsophageal squamous cell carcinoma - کارسینوم سلول سنگفرشی مریbladder transitional cell carcinoma - کارسینوم سلول گذار مثانهextracellular-regulated kinase - کیناز تنظیم شده خارج سلولی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Loss of tumor suppressor activity is a frequent event in the formation and progression of tumors and has been listed as an important hallmark of cancers. Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor gene which is reported to be frequently down-regulated in a variety of human cancers including pancreas, colon, bladder, head-and-neck, ovarian, breast cancers, gastric, lung cancers. It is also reported to be implicated in several types of pathologies such as cardiac hypertrophy, atherosclerosis, and SLE-like lymphoproliferative diseases. Moreover, MTUS1-encoded proteins are shown to be involved in the regulation of vital cellular processes such as proliferation, differentiation, DNA repair, inflammation, vascular remodeling and senescence. However, the current knowledge is very limited about the role of this gene in human cancers as well as other type diseases. Besides, there is no literature report which summarizes and criticizes the importance of MTUS1 in the cellular processes, especially in the processes of carcinogenesis. Accordingly, in this comprehensive review, we tried to shed light on the role of tumor suppressor MTUS1/ATIP in health and disease, putting special emphasis on its role in the development and progression of human cancers as well as associated molecular mechanisms and the reasons behind MTUS1/ATIP deficiency, which have been not well documented previously.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 626, 30 August 2017, Pages 54-63
Journal: Gene - Volume 626, 30 August 2017, Pages 54-63
نویسندگان
Ibrahim Bozgeyik, Onder Yumrutas, Esra Bozgeyik,