کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5594225 | 1571295 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD](/preview/png/5594225.png)
چکیده انگلیسی
Low muscle oxidative capacity contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Near-infrared spectroscopy (NIRS) allows non-invasive determination of the muscle oxygen consumption (mVÌO2) recovery rate constant (k), which is proportional to oxidative capacity assuming two conditions are met: 1) exercise intensity is sufficient to fully-activate mitochondrial oxidative enzymes; 2) sufficient O2 availability. We aimed to determine reproducibility (coefficient of variation, CV; intraclass correlation coefficient, ICC) of NIRS k assessment in the gastrocnemius of 64 participants with (FEV1 64 ± 23%predicted) or without COPD (FEV1 98 ± 14%predicted). 10-15 s dynamic contractions preceded 6 min of intermittent arterial occlusions (5-10 s each, â¼250 mmHg) for k measurement. k was lower (P < 0.05) in COPD (1.43 ± 0.4 minâ1; CV = 9.8 ± 5.9%, ICC = 0.88) than controls (1.74 ± 0.69 minâ1; CV = 9.9 ± 8.4%; ICC = 0.93). Poor k reproducibility was more common when post-contraction mVÌO2 and deoxygenation were low, suggesting insufficient exercise intensity for mitochondrial activation and/or the NIRS signal contained little light reflected from active muscle. The NIRS assessment was well tolerated and reproducible for muscle dysfunction evaluation in COPD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 235, January 2017, Pages 18-26
Journal: Respiratory Physiology & Neurobiology - Volume 235, January 2017, Pages 18-26
نویسندگان
Alessandra Adami, Robert Cao, Janos Porszasz, Richard Casaburi, Harry B. Rossiter,