Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes

From the onset of development in culture, the iPSC-CMs population includes nodal, atrial, and ventricular APs and a broad spectrum of transitional phenotypes. The most readily distinguishable phenotype is atrial, which appears only transiently yet dominates at 57-70 days of evolution.