کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5603658 | 1575807 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Electrophysiological mechanisms of long and short QT syndromes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
The QT interval on the human electrocardiogram is normally in the order of 450Â ms, and reflects the summated durations of action potential (AP) depolarization and repolarization of ventricular myocytes. Both prolongation and shortening in the QT interval have been associated with ventricular tachy-arrhythmias, which predispose affected individuals to sudden cardiac death. In this article, the molecular determinants of the AP duration and the causes of long and short QT syndromes (LQTS and SQTS) are explored. This is followed by a review of the recent advances on their arrhythmogenic mechanisms involving reentry and/or triggered activity based on experiments conducted in mouse models. Established and novel clinical risk markers based on the QT interval for the prediction of arrhythmic risk and cardiovascular mortality are presented here. It is concluded by a discussion on strategies for the future rational design of anti-arrhythmic agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: IJC Heart & Vasculature - Volume 14, March 2017, Pages 8-13
Journal: IJC Heart & Vasculature - Volume 14, March 2017, Pages 8-13
نویسندگان
Gary Tse, Yin Wah Fiona Chan, Wendy Keung, Bryan P Yan,