β3-Adrenergic receptor regulates hepatic apolipoprotein A-I gene expression

β3-AR activation increased the activities of the apoA-I promoter, HNF-4, and HNF-3, which might account for the mechanism of β3-AR-mediated upregulation of hepatic apoA-I expression. β3-AR might exert an anti-atherosclerotic effect by upregulating hepatic apoA-I expression and promoting the cholesterol reverse transport process.