Can iPCSK9-induced hypocholesterolemia starve cancer cells?

- Low-density lipoproteins provide cholesterol to peripheral cells, including cancer cells.
- Cancer cells have higher cholesterol requirements to sustain tumor growth.
- Low-density lipoproteins <25 mg/dL have been reported with PCSK9 inhibitors on top of a statin.
- A combination of cholesterol-lowering drugs could find use in cancer therapy.
- Clinical validation that cholesterol-lowering drugs slow cancer progression and metastasis is required.