کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5621797 1579185 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Full Length ArticleAssociation of impaired renal function with venous thrombosis: A genetic risk score approach
ترجمه فارسی عنوان
طول کامل ماده ارتباطی اختلال عملکرد کلیه با ترومبوز وریدی: رویکرد نمره خطر ژنتیکی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی


- We identified a genetic risk score based on 9 eGFR-associated SNPs that impact on the risk of VT.
- Individuals with a score higher than 11 are associated with a 1.42 increased risk of disease.
- Biological mechanisms underlying this association need to be further investigated.

ObjectiveThe association between impaired kidney function and venous thrombosis has been previously reported but supportive data are still sparse. We here wish to strengthen this association by investigating, by use of a genetic risk score approach, whether single nucleotide polymorphisms (SNPs) known to decrease the estimated glomerular filtration rate (eGFR), a surrogate marker for renal dysfunction, are associated with increased risk of venous thrombosis.Approach and resultsFifty-one polymorphisms selected from the literature to robustly associate with eGFR were first tested for association with venous thrombosis in a French case-control collection of 1953 patients and 2338 healthy individuals. This led to the identification of a genetic risk score based on 9 polymorphisms that strongly associated with increased risk (odds ratio (OR) = 1.09 [1.06-1.15], p = 1.44 · 10− 7). This genetic score association replicated (OR = 1.18 [1.11-1.26], p = 8.86 · 10− 8) in an independent sample of 1289 patients and 1049 healthy controls part of the Dutch MEGA study. We then categorized the genetic score distribution observed in the combined samples into quintiles. Compared with the lowest quintile, the OR for increased risk of disease associated with the second, third, fourth and fifth quintiles were 1.13 [0.94-1.16], 1.47 [1.22-1.77], 1.52 [1.26-1.82] and 1.70 [1.41-2.05], respectively.ConclusionsUsing a genetic risk score analysis, our study provides new elements supporting the association between impaired renal function and the risk of venous thrombosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 158, October 2017, Pages 102-107
نویسندگان
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