کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5622215 | 1579195 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
CorrespondenceStability of direct oral anticoagulants in whole blood and plasma from patients in steady state treatment
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
- In whole blood, all DOACs were stable for up to 2Â h.
- In plasma, rivaroxaban and apixaban were stable for up to 8 h at 20-25 °C.
- In plasma, rivaroxaban and apixaban were stable for up to 48 h at 5 °C.
- Rivaroxaban was the only freeze-thaw stable DOAC.
- Laboratories have to consider these differences before analysis of DOACs.
Using functional haemostasis assays, we demonstrated important differences in stability of direct oral anticoagulants (DOACs) in citrated whole blood and plasma from DOAC treated patients. Laboratories and clinicians should take this into consideration and adjust clinical practices accordingly.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 148, December 2016, Pages 107-110
Journal: Thrombosis Research - Volume 148, December 2016, Pages 107-110
نویسندگان
Rie McGrail, Jesper Revsholm, Peter H. Nissen, Erik L. Grove, Anne-Mette Hvas,