کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5622215 1579195 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CorrespondenceStability of direct oral anticoagulants in whole blood and plasma from patients in steady state treatment
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
CorrespondenceStability of direct oral anticoagulants in whole blood and plasma from patients in steady state treatment
چکیده انگلیسی


- In whole blood, all DOACs were stable for up to 2 h.
- In plasma, rivaroxaban and apixaban were stable for up to 8 h at 20-25 °C.
- In plasma, rivaroxaban and apixaban were stable for up to 48 h at 5 °C.
- Rivaroxaban was the only freeze-thaw stable DOAC.
- Laboratories have to consider these differences before analysis of DOACs.

Using functional haemostasis assays, we demonstrated important differences in stability of direct oral anticoagulants (DOACs) in citrated whole blood and plasma from DOAC treated patients. Laboratories and clinicians should take this into consideration and adjust clinical practices accordingly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Thrombosis Research - Volume 148, December 2016, Pages 107-110
نویسندگان
, , , , ,