کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626703 1406326 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Priming theta burst stimulation enhances motor cortex plasticity in young but not old adults
ترجمه فارسی عنوان
تحریک لرزشی تتا باعث افزایش پوسیدگی قشر حرکتی در بزرگسالان جوان، اما نه ساله می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


- Priming theta burst stimulation (TBS) modulates motor plasticity in young subjects.
- Priming with TBS was ineffective at increasing plasticity in elderly adults.
- Priming TBS may not be beneficial in neurological conditions common in the elderly.

BackgroundPrimary motor cortex neuroplasticity is reduced in old adults, which may contribute to the motor deficits commonly observed in the elderly. Previous research in young subjects suggests that the neuroplastic response can be enhanced using non-invasive brain stimulation (NIBS), with a larger plastic response observed following priming with both long-term potentiation (LTP) and depression (LTD)-like protocols. However, it is not known if priming stimulation can also modulate plasticity in older adults.ObjectiveTo investigate if priming NIBS can be used to modulate motor cortical plasticity in old subjects.MethodsIn 16 young (22.3 ± 1.0 years) and 16 old (70.2 ± 1.7 years) subjects, we investigated the response to intermittent theta burst stimulation (iTBS; LTP-like) when applied 10 min after sham stimulation, continuous TBS (cTBS; LTD-like) or an identical block of iTBS. Corticospinal plasticity was assessed by recording changes in motor evoked potential (MEP) amplitude.ResultsIn young subjects, priming with cTBS (cTBS + iTBS) resulted in larger MEPs than priming with either iTBS (iTBS + iTBS; P = 0.001) or sham (sham + iTBS; P < 0.0001), while larger MEPs were seen following iTBS + iTBS than sham + iTBS (P < 0.0001). In old subjects, the response to iTBS + iTBS was not different to sham + iTBS (P > 0.9), whereas the response to cTBS + iTBS was reduced relative to iTBS + iTBS (P = 0.02) and sham + iTBS (P = 0.04).ConclusionsPriming TBS is ineffective for modifying M1 plasticity in older adults, which may limit the therapeutic use of priming stimulation in neurological conditions common in the elderly.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Stimulation - Volume 10, Issue 2, March–April 2017, Pages 298-304
نویسندگان
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