|کد مقاله||کد نشریه||سال انتشار||مقاله انگلیسی||ترجمه فارسی||نسخه تمام متن|
|5630311||1580366||2017||8 صفحه PDF||سفارش دهید||دانلود رایگان|
- Effects of escitalopram or herbal treatment on the response to LPS were assessed.
- Escitalopram augmented LPS-induced TNFÎ± and altered the kinetics of IL-1Î² secretion.
- Escitalopram marginally reduced sickness behavior.
- Herbal treatment abolished LPS-induced IL-1Î² and TNFÎ± secretion.
- Herbal treatment diminished LPS-induced sickness behavior.
Studies suggest that inflammation is involved in the pathophysiology of depression. The present study examined the effects of the commonly used antidepressant escitalopram, in comparison with a novel herbal treatment (NHT) consisted of Crataegus pinnatifida, Triticum aestivum, Lilium brownii and Fructus Ziziphus jujuba, on cytokine and behavioral responses to an immune challenge. Escitalopram augmented lipopolysaccharide-induced tumor necrosis factor (TNF)-Î± peripheral secretion and induced a faster kinetics of interleukin-1Î² secretion, while marginally reducing sickness behavior. NHT, on the other hand, completely abolished lipopolysaccharide-induced interleukin-1Î² and TNFÎ± peripheral secretion and diminished sickness behavior. These findings may have implications for the treatment of depressive symptoms associated with immune activation.
Journal: Journal of Neuroimmunology - Volume 309, 15 August 2017, Pages 111-118