کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5631083 1580857 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood
چکیده انگلیسی


- Hippocampal subfield and subregion volumes were measured in children and adults.
- Adults had smaller CA3-dentate gyrus volumes as compared to children.
- Non-linear age differences were identified in CA1-2 and hippocampal body volumes.
- Smaller CA3-dentate gyrus volume explained better associative memory with age.

Associative memory develops into adulthood and critically depends on the hippocampus. The hippocampus is a complex structure composed of subfields that are functionally-distinct, and anterior-posterior divisions along the length of the hippocampal horizontal axis that may also differ by cognitive correlates. Although each of these aspects has been considered independently, here we evaluate their relative contributions as correlates of age-related improvement in memory. Volumes of hippocampal subfields (subiculum, CA1-2, CA3-dentate gyrus) and anterior-posterior divisions (hippocampal head, body, tail) were manually segmented from high-resolution images in a sample of healthy participants (age 8-25 years). Adults had smaller CA3-dentate gyrus volume as compared to children, which accounted for 67% of the indirect effect of age predicting better associative memory via hippocampal volumes. Whereas hippocampal body volume demonstrated non-linear age differences, larger hippocampal body volume was weakly related to better associative memory only when accounting for the mutual correlation with subfields measured within that region. Thus, typical development of associative memory was largely explained by age-related differences in CA3-dentate gyrus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 153, June 2017, Pages 75-85
نویسندگان
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