کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5636320 | 1406667 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Progress of clinical practice on the management of burn-associated pain: Lessons from animal models
ترجمه فارسی عنوان
پیشرفت عملکرد بالینی در مدیریت درد مبتلا به سوختگی: درس های مدل حیوانات
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کلمات کلیدی
CFAFTBFull thickness burnOIHSNLTBSAGFRNMDASIRSN-methyl-d-aspartic acidcomplete Freund's adjuvant - adjuvant دوست کاملAllodynia - آلودینیا post-traumatic stress disorder - اختلال استرس پس از ضربهPTSD - اختلال استرسی پس از ضایعه روانیsin - بدونLocal anesthetics - بی حسکننده موضعیAnalgesia - بیهوشیBurn pain - درد را ببوسTotal body surface area - سطح کل بدنSystemic inflammatory response syndrome - سندرم پاسخ سیستماتیک التهابیPharmacodynamics - فارماکودینامیکPharmacokinetics - فارماکوکینتیکAnimal models - مدل های حیوانیGlomerular filtration rate - نرخ فیلتراسیون گلومرولیOpioid-induced hyperalgesia - هیپرآلژزی ناشی از OpioidHyperalgesia - پردردی یا هایپرآلژزیspinal nerve ligation - پیوند عصب ستون فقرات
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
مراقبت های ویژه و مراقبتهای ویژه پزشکی
چکیده انگلیسی
Opioid-based analgesics provide the mainstay for attenuating burn pain, but they have a myriad of side effects including respiratory depression, nausea, impaired gastrointestinal motility, sedation, dependence, physiologic tolerance, and opioid-induced hyperalgesia. To test and develop novel analgesics, validated burn-relevant animal models of pain are indispensable. Herein we review such animal models, which are mostly limited to rodent models of burn-induced, inflammatory, and neuropathic pain. The latter two are pain syndromes that provide insight into the pain caused by systemic pro-inflammatory cytokines and direct injury to nerves (e.g., after severe burn), respectively. To date, no single animal model optimally mimics the complex pathophysiology and pain that a human burn patient experiences. No currently available burn-pain model examines effects of pharmacological intervention on wound healing. As cornerstones of pain and wound healing, pro-inflammatory mediators may be utilized for insight into both processes. Moreover, common clinical concerns such as systemic inflammatory response syndrome and multiple organ dysfunction remain unaddressed. For development of analgesics, these aberrations can significantly alter the potential efficacy and/or adverse effects of a prescribed analgesic following burn trauma. We therefore suggest that a multi-model strategy would be the most clinically relevant when evaluating novel analgesics for use in burn patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Burns - Volume 42, Issue 6, September 2016, Pages 1161-1172
Journal: Burns - Volume 42, Issue 6, September 2016, Pages 1161-1172
نویسندگان
Matthew K. McIntyre, John L. Clifford, Christopher V. Maani, David M. Burmeister,