کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5640194 1406807 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Genetic response in masseter muscle after orthognathic surgery in comparison with healthy controls - A Microarray study
ترجمه فارسی عنوان
پاسخ ژنتیکی در عضله توده عضلانی بعد از عمل جراحی ارتوآنتیواتیک در مقایسه با کنترل سالم - مطالعهی میکروارگانیسم
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

One third of adult patients with orthognathic surgery of a prognathic or retrognathic mandible show relapse. The sagittal split osteotomy of the mandible leads to a displacement of both parts up to 10 mm without any changes of muscle attachment. Changed mandible length needs adaptation of muscle capacity because of changed force to moment ratio. The aim of this Microarray study was to analyze the general genetic response of masseter muscle in patients with retrognathism or prognathism of the mandible six months after surgery in comparison with healthy untreated controls. We found in tissue samples from masseter muscle a reduction of different entities between patients and controls but less in retrognathic than in prognathic patients (274/429). The different entities to controls in prognathia were reduced from 1862 to 1749 but increased in retrognathia from 1070 to 1563. We have to consider that the total amount of different entities to the controls is higher in patients with prognathic mandible (7364) because of their strong genetic controlled development compared with that in patients with retrognathic mandible (4126), which is more environmentally influenced.It can be concluded that function follows form after surgical change with high inheritance. In retrognathic patients the adaptation could be delayed or the capacity of regeneration potential is not sufficient.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 45, Issue 4, April 2017, Pages 547-551
نویسندگان
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