Bone penetrance of locally administered vancomycin powder in a rat femur fracture model

Locally administered vancomycin provides drug delivery in excess of IV dosing for approximately 48 h after intervention. Exponential decay demonstrates rapid removal of drug to near undetectable levels in bone, plasma, and local soft tissue thereafter in a rat model. Local delivery may generate concentrations exceeding that achievable by steady state systemic dosing for 48 h.