کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5655216 1407312 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure
چکیده انگلیسی

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are part of the armamentarium for the treatment of type 2 diabetes (T2D), although recent guidelines have mainly recommended their use on top of oral treatments when a single or combination of two or three oral hypoglycaemic agents has failed to lower HbA1c levels below the individualized target range. In such situations, the decision to use GLP-1RAs is mostly driven by their high level of efficacy, their effect on body weight balance and their safety considerations, such as low hypoglycaemic risk. According to the current guidelines, GLP-1RAs may also be used in T2D patients in addition to basal insulin, following specialist-care advice, in patients who are more severely obese or who may not have the capacity to handle the complexities of a multiple daily injection (MDI) insulin regimen. The present review looks at the scientific evaluations performed in this context as well as the clinical trials assessing the use of GLP-1RAs in combination with intensive insulin therapy as further step-up therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes & Metabolism - Volume 43, Supplement 1, April 2017, Pages 2S34-2S38
نویسندگان
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