کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5664409 1407704 2017 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rejuvenation of aged hematopoietic stem cells
ترجمه فارسی عنوان
جوان سازی سلول های بنیادی خون مادر
کلمات کلیدی
سلول های بنیادی هماتوپوئیت، سالخورده، جوانسازی موقعیت مناسب، جایگاه،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Until recently, there was broad consensus in the stem cell aging field that the phenotype of aged hematopoietic stem cells (HSCs) is fixed-dominated by cell-intrinsic regulatory mechanisms that cannot be altered by pharmacological or genetic means. The conventional thinking was that HSC aging could not be reverted by therapeutic intervention. This paradigm has started to shift dramatically, primarily because hallmarks of aged HSCs have been successfully reverted by distinct experimental approaches by multiple laboratories. We will discuss in this review these hallmarks of HSCs aging and the novel approaches that successfully ameliorated or even reverted aging-associated hallmarks of aged HSCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Hematology - Volume 54, Issue 1, January 2017, Pages 51-55
نویسندگان
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