کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5665418 1407749 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of galectin-3 in autoimmune and non-autoimmune nephropathies
ترجمه فارسی عنوان
نقش گالککتین 3 در نفروپاتی های خود ایمنی و غیر خود ایمنی
کلمات کلیدی
گالکتین-3، گلومرولونفریت لوپوس، فیبروز کلیه، سندرم قلبی-ریوی، محور رینین-آنژیوتانسین-آلدوسترون، لوپوس اریتماتوی سیستمیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Galectin-3 can potentially hinder lupus nephritis reducing autoantigen availability.
- Galectin-3 can modulate pan-organ inflammatory, healing and fibrotic responses.
- Galectin-3 is involved in NF-kβ, Wnt, TGF-β, Leptin and Aldosterone pathways.
- Galectin-3 may link renal, cardiovascular and metabolic disease.
- Galectin-3 contributes to renal cell homeostasis, polarization and regeneration.

Galectins are evolutionary conserved β-galactoside binding proteins with a carbohydrate-recognition domain (CRD) of approximately 130 amino acids. In mammals, 15 members of the galectin family have been identified and classified into three subtypes according to CRD organization: prototype, tandem repeat-type and chimera-type galectins. Galectin-3 (gal-3) is the only chimera type galectin in vertebrates containing one CRD linked to an unusual long N-terminal domain which displays non-lectin dependent activities. Although recent studies revealed unique, pleiotropic and context-dependent functions of gal-3 in both extracellular and intracellular space, gal-3 specific pathways and its ligands have not been clearly defined yet. In the kidney gal-3 is involved in later stages of nephrogenesis as well as in renal cell cancer. However, gal-3 has recently been associated with lupus glomerulonephritis, with Familial Mediterranean Fever-induced proteinuria and renal amyloidosis. Gal-3 has been studied in experimental acute kidney damage and in the subsequent regeneration phase as well as in several models of chronic kidney disease, including nephropathies induced by aging, ischemia, hypertension, diabetes, hyperlipidemia, unilateral ureteral obstruction and chronic allograft injury. Because of the pivotal role of gal-3 in the modulation of immune system, wound repair, fibrosis and tumorigenesis, it is not surprising that gal-3 can be an intriguing prognostic biomarker as well as a promising therapeutic target in a great variety of diseases, including chronic kidney disease, chronic heart failure and cardio-renal syndrome. This review summarizes the functions of gal-3 in kidney pathophysiology focusing on the reported role of gal-3 in autoimmune diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 16, Issue 1, January 2017, Pages 34-47
نویسندگان
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