کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5665448 1407751 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
T cell subpopulations in juvenile idiopathic arthritis and their modifications after biotherapies
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
T cell subpopulations in juvenile idiopathic arthritis and their modifications after biotherapies
چکیده انگلیسی

Inflammatory T cells are thought to be central to the pathogenesis of juvenile idiopathic arthritis. In particular, recent evidence has underlined the importance of a balance between Th17 and Treg cells. Several mechanisms have come to light that control this reciprocal relationship. Moreover, it has been shown that in certain conditions, Th17 cells can shift toward a nonclassic Th1 phenotype. Anti-rheumatic biologic therapies may interfere with these mechanisms and re-establish immune tolerance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 15, Issue 12, December 2016, Pages 1141-1144
نویسندگان
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