کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5665484 1407753 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The viral paradigm in type 1 diabetes: Who are the main suspects?
ترجمه فارسی عنوان
پارادایم ویروسی در دیابت نوع 1: چه کسانی مظنون اصلی هستند؟
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی

Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of pancreatic beta cells in the islets of Langerhans. Although genetic predisposition plays an important role in T1D development, studies of identical twins suggest that environmental factors such as viruses and other pathogens may be critical triggers either through direct cytolytic effect and gradual beta cell destruction, or by bystander activation of the immune system. In addition, viruses may circumvent the host immune response and have the capacity to establish chronic lifelong infections. The association of various viral infections with the induction of T1D has been extensively studied at the serological and epidemiological level. However, there is still little evidence from studies of human pancreas to confirm their presence or a causal role in disease pathogenesis. In this review, we identify possible suspects for viral triggers of disease and explain their potential roles in the “viral paradigm” of T1D.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autoimmunity Reviews - Volume 15, Issue 10, October 2016, Pages 964-969
نویسندگان
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