کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5666031 | 1407782 | 2016 | 5 صفحه PDF | دانلود رایگان |
- A total of 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates were analyzed.
- MRSA prevalence rates in pig farms were high.
- All livestock-associated MRSA were CC398.
- Resistance rates differed significantly between LA- and HA-MRSA.
- LA-MRSA had significantly less recognized virulence genes than HA-MRSA.
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S. aureus (HA-MRSA) and assessed carriage rates. Samples from pigs (n = 330), occupationally exposed personnel (n = 63), the farm environment (n = 134), and hospital patients (n = 220) were obtained. Approximately 50% (166/330) of pigs were MRSA positive. All LA-MRSA were resistant to tetracycline, compared to only 8% of HA-MRSA (P < 0.001). In contrast, HA-MRSA isolates showed significantly higher resistance rates to quinolones (81% versus 7%; P < 0.001). All strains isolated from occupationally exposed personnel (61.9%; 39/63) belonged to CC398. HA-MRSA isolates were diversely distributed, with predominance of CC5 (62.7%). Human strains carried significantly more virulence genes than porcine strains, especially exotoxins (P < 0.001) and immune-evasion cluster genes (P < 0.001). There were significant differences in resistance patterns and recognized genotypic virulence loci between LA-MRSA and HA-MRSA.
Journal: Diagnostic Microbiology and Infectious Disease - Volume 86, Issue 4, December 2016, Pages 417-421