کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666850 1591748 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic combinations of polymyxins
ترجمه فارسی عنوان
ترکیبی از ترکیبات پلی مکسین
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


- This is a review of recent in vitro, in vivo and clinical studies of polymyxin synergy.
- In vitro, many polymyxin combinations displayed synergistic killing.
- Animal studies offered limited evidence for the use of polymyxin combinations.
- Clinical studies provided divergent findings on the use of polymyxin combinations.
- Large clinical trials are underway to clarify the use of polymyxin combinations.

The proliferation of extensively drug-resistant Gram-negative pathogens has necessitated the therapeutic use of colistin and polymyxin B. However, treatment failures with polymyxin monotherapies and the emergence of polymyxin resistance have catalysed the search for polymyxin combinations that synergistically kill polymyxin-susceptible and -resistant organisms. This mini-review examines recent (2011-2016) in vitro and in vivo studies that have attempted to identify synergistic polymyxin combinations against Pseudomonas aeruginosa, Klebsiella pneumoniae and Acinetobacter baumannii. Clinical evidence for the use of combination regimens is also discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 48, Issue 6, December 2016, Pages 607-613
نویسندگان
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