کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5668084 1592333 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis
ترجمه فارسی عنوان
بیان التهاب و ویروسی از ویروس سیتومگالوویروس در بیماران مبتلا به سپسیس
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی


- CMV viremia developed in 28% of critically ill patients with sepsis due to bloodstream infection.
- Assessment of expression levels of genes encoding inflammasome-related proteins showed that critically ill patients who developed sepsis following recent surgery had significantly lower apoptosis-associated speck-like protein (ASC) mRNA levels than those without surgery.
- Development of high-grade CMV viremia (>500 copies/mL) was significantly associated with Caspase −1 (CASP) mRNA levels.

BackgroundCMV viremia is a contributor to poor outcomes in critically ill patients with sepsis.ObjectivesTo assess the expression levels of genes encoding inflammasome-related proteins in the development of CMV viremia in critically ill patients with sepsis.Study designA cohort of CMV-seropositive critically ill patients with sepsis due to bloodstream infection underwent weekly testing for CMV viremia. Blood samples to evaluate mRNA levels of genes encoding CASP1, ASC, NLRP1, NLRP3, and NLRP12 were collected at the time of enrollment. Clinical outcomes were assessed at 30 days or until death/discharge from ICU.ResultsCMV viremia was documented in 27.5% (8/29) of the patients, a median of 7 days after the onset of bacteremia. Patients with sepsis who developed CMV viremia had higher CASP1 although this was not statistically significant (relative mean 3.6 vs 1.8, p = 0.13). Development of high grade CMV viremia however, was significantly associated with CASP1; septic patients who developed high grade CMV viremia had significantly higher CASP1than all other patients (relative mean 5.5 vs 1.8, p = 0.016).ConclusionsThese data document possible involvement of inflammasome in the pathogenesis of CMV. Regulating the host immune response by agents that target these genes may have implications for improving CMV-related outcomes in these patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Virology - Volume 93, August 2017, Pages 8-14
نویسندگان
, , , , ,