کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5668093 | 1592333 | 2017 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015 Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015](/preview/png/5668093.png)
- Significant increase in CV-A10 severe HFMD cases in Xiamen City in 2015.
- Genetic differences exist between severe and mild CV-A10 HFMD cases.
- Provides information for development of diagnostic assay and vaccines.
BackgroundCoxsackievirus A10 (CV-A10) is one of the etiological agents associated with hand, foot and mouth disease (HFMD) and usually causes mild cases. During 2009-2014, no severe cases caused by CV-A10 was reported in Xiamen, China, however, an increase in cases was seen in 2015.ObjectivesWe aimed to perform a retrospective molecular epidemiological analysis of HFMD associated with CV-A10 infections in Xiamen.Study designCV-A10 VP1 (n = 41) capsid and full-length or near full-length genomes (n = 14) were sequenced. Phylogenetic trees were constructed based on these sequences and other reference sequences and nucleotide and amino acid changes were characterized.ResultsFrom 2009-2014, no laboratory-confirmed CV-A10 infections associated with severe cases were identified, however, in 2015, 39% (7/18) of severe HFMD cases were CV-A10 infections. Sequence analysis of severe and non-severe CV-A10 HFMD cases determined that severe cases predominantly clustered with an emerging clade E lineage A strain which contained 4 nucleotide changes in 5ⲠUTR and 5 amino acid substitutions in structural and non-structural proteins.ConclusionsThe results indicate CV-A10 infection may be emerging as a new and major cause of severe HFMD and CV-A10 surveillance should be increased and considered in HFMD prevention and control strategies.
Journal: Journal of Clinical Virology - Volume 93, August 2017, Pages 20-24