کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5668737 | 1407916 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Alcoholism is a strong independent risk factor for unfavorable outcome in meningitis.
- Early intensive care treatment of is pertinent to avoid unfavorable disease outcome.
- Seizures are common and warrant caution of development of an alcohol withdrawal syndrome.
SummaryObjectivesTo study clinical features and outcome of community-acquired bacterial meningitis in alcoholic patients.MethodsPatients with a history of alcoholism were selected from our nationwide, prospective cohort on community-acquired bacterial meningitis performed from March 2006 to October 2014. Data on patient history, symptoms and signs on admission, treatment, and outcome were prospectively collected.ResultsOf 1359 included episodes, 88 episodes (6%) occurred in 88 alcoholic patients. Seizures as presenting symptom were present in 18% alcoholic patients, and 23% presented with co-existing pneumonia. Causative organisms were Streptococcus pneumoniae in 76%, Listeria monocytogenes in 8%, and Neisseria meningitidis in 6% of patients. A high rate of systemic complications occurred with respiratory failure in 40% and endocarditis in 9% of patients. Outcome was unfavorable in 58% of alcoholic patients, and 25% died. Alcoholism was associated with unfavorable outcome in a multivariate analysis (OR 1.96; 95% CI 1.12-3.46; PÂ =Â 0.019), but not with death (OR 0.76; 95% CI 0.35-1.68; PÂ =Â 0.762).ConclusionAlcoholic bacterial meningitis patients often have an unfavorable outcome, which appears to result from a high rate of systemic complications, mainly respiratory failure. Seizures are common in alcoholic patients and warrant caution of development of an alcohol withdrawal syndrome.
Journal: Journal of Infection - Volume 74, Issue 4, April 2017, Pages 352-357