کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685055 | 1597929 | 2017 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Noncoding RNAs in the development, diagnosis, and prognosis of colorectal cancer
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کلمات کلیدی
MPEIBDsnoRNAncRNApiRNAMREcircRNAParnaNon-coding RNA - RNA غیرکد کننده، RNA غیرترجمه شوندهsmall nucleolar RNA - RNA کوچک هسته ایInflammatory bowel disease - بیماریهای التهابی رودهEMT - تکنسین فوریتهای پزشکیColorectal cancer - سرطان روده بزرگceRNA - سینهCRC - کد افزونگی دورهای epithelial-to-mesenchymal transition - گذار اپیتلیال به مزانشیمال
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
More than 90% of the human genome is actively transcribed, but less than 2% of the total genome encodes protein-coding RNA, and thus, noncoding RNA (ncRNA) is a major component of the human transcriptome. Recently, ncRNA was demonstrated to play important roles in multiple biological processes by directly or indirectly interfering with gene expression, and the dysregulation of ncRNA is associated with a variety of diseases, including cancer. In this review, we summarize the function and mechanism of miRNA, long intergenic ncRNA, and some other types of ncRNAs, such as small nucleolar RNA, circular ncRNA, pseudogene RNA, and even protein-coding mRNA, in the progression of colorectal cancer (CRC). We also presented their clinical application in the diagnosis and prognosis of CRC. The summary of the current state of ncRNA in CRC will contribute to our understanding of the complex processes of CRC initiation and development and will help in the discovery of novel biomarkers and therapeutic targets for CRC diagnosis and treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Translational Research - Volume 181, March 2017, Pages 108-120
Journal: Translational Research - Volume 181, March 2017, Pages 108-120
نویسندگان
Mingjiao Weng, Di Wu, Chao Yang, Haisheng Peng, Guangyu Wang, Tianzhen Wang, Xiaobo Li,