Cup-to-Disc Ratio Asymmetry in U.S. Adults

Vertical cup-to-disc ratio asymmetry is predictive of prevalent glaucoma, but the PPV remains low even at high degrees of asymmetry. Vertical cup-to-disc ratio asymmetry should initiate a more comprehensive glaucoma workup, especially in individuals with additional risk factors, but it is not appropriate as a screening metric for glaucoma.