کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
570554 1433801 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lower folate levels in schizophrenia: A meta-analysis
ترجمه فارسی عنوان
سطح فولات کمتر در اسکیزوفرنی: متا تجزیه و تحلیل
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
چکیده انگلیسی


• Folate deficiency may be associated with schizophrenia.
• The folate levels of schizophrenia cases were lower than that of healthy controls.
• The 20 published articles of meta-analysis included 1463 cases and 1276 controls.

This meta-analysis aimed to estimate the association between folate level and schizophrenia in order to provide the evidence for the treatment of schizophrenia. Data were extracted from all the studies meeting our inclusion and exclusion criteria. The association between the folate level and schizophrenia was evaluated by the standardized mean difference (SMD) and 95% confidence interval (CI). The 20 published articles of our meta-analysis included 1463 (53.4%) cases and 1276 (46.6%) controls. The folate level was significantly lower in schizophrenia cases than in healthy controls. Subgroup analysis showed the folate level was lower in cases from Asia subgroup than in healthy controls. Sensitivity analysis showed that the current results were credible and reliable and the funnel plots indicated no publication bias in our meta-analysis. Our study indicates that schizophrenia patients may have lower folate levels. More epidemiological and laboratory studies are still needed to confirm whether it is necessary to supplement folate in schizophrenia patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 245, 30 November 2016, Pages 1–7
نویسندگان
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