کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716254 1606643 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Case studyMucoepidermoid carcinoma with extensive spindled morphology and melanocytic marker expression
ترجمه فارسی عنوان
مطالعه موردی کارسینوم مغز اپیدرموئید با مورفولوژی اسپیندل و بیانگر مارکر ملانوسیتیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی


- The first case of mucoepidermoid carcinoma (MEC) with marked spindled morphology
- The first case of MEC expressing melanocytic markers and yielding melanin granules
- Molecularly confirmed diagnosis of MEC by CRTC3-MAML2 fusion gene product detection
- A novel variant of MEC, which broadens the histologic spectrum of MEC

SummaryMucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland. Albeit common, histologic variants have rarely been noted in MEC. Here, we report a 49-year-old man with a sublingual gland tumor. Histologically, the tumor was composed of spindle cells arranged in interlacing fascicules or globular nests. A few bland small glands containing mucous cells were also scattered. The spindle tumor cells completely lacked immunoreactivity for cytokeratin, and exhibited immunoreactivity for vimentin, S-100, HMB-45, Melan A, and SOX10. The tumor was initially suspected to be clear cell sarcoma, malignant melanoma, or perivascular epithelioid cell tumor with a few entrapped nonneoplastic duct epitheliums. However, reverse-transcription polymerase chain reaction revealed the CRTC3-MAML2 fusion gene product diagnostic of MEC. In fact, a very minor component of the epithelial cells was reminiscent of conventional MEC, whereas major spindled tumor cells possessed markedly altered differentiation. This is the first case report of MEC with extensive spindled morphology and melanocytic marker expression.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 67, September 2017, Pages 181-186
نویسندگان
, , , , , , , , , , , , , , , , , , , , , , , , , ,