کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716711 1411166 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fibrolamellar carcinoma: A histologically unique tumor with unique molecular findings
ترجمه فارسی عنوان
کارسینوم فیبرولمامالار: تومور منحصر به فرد بافت شناسی با یافته های مولکولی منحصر به فرد است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
چکیده انگلیسی
Fibrolamellar carcinoma is a unique type of hepatocellular carcinoma with a distinctive predilection for young patients without underlying liver disease, characteristic large neoplastic cells with intervening, dense fibrosis, co-expression of keratin 7 and CD68 and activation of protein kinase A (most often by formation of DNAJB1-PRKACA). Fibrolamellar carcinoma has a similar prognosis to conventional hepatocellular carcinomas arising in non-cirrhotic livers. The current American Joint Cancer Committee staging system does not provide optimal stratification of patients with fibrolamellar carcinoma and an alternate systems should be considered in the future. The only effective treatment for fibrolamellar carcinoma is complete resection. Novel therapies may be on the horizon as investigation into the molecular biology of fibrolamellar carcinoma continues.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Diagnostic Pathology - Volume 34, Issue 2, March 2017, Pages 146-152
نویسندگان
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