کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5719218 | 1607418 | 2017 | 8 صفحه PDF | دانلود رایگان |

ObjectivesTo assess whether ad libitum consumption of thiamin-fortified fish sauce over 6 months yields higher erythrocyte thiamin diphosphate concentrations (eTDP) among women of childbearing age and their children aged 12-59âmonths compared with control sauce containing no thiamin.Study designIn this double-blind, randomized controlled efficacy trial, 276 nonpregnant, nonlactating women (18-45âyears of age) and their families in Prey Veng, Cambodia, were randomized to receive 1 of 3 fish sauce formulations: low thiamin concentration (low, 2âg/L), high thiamin concentration (high, 8âg/L), or a control (no thiamin) fish sauce. Baseline (tâ=â0) and endline (tâ=â6âmonths) eTDP were measured with the use of high-performance liquid chromatography with a fluorescence detector.ResultsFish sauce consumption did not differ between treatment groups (Pâ=â.19). In intent-to-treat analysis, women's baseline-adjusted endline eTDP (mean; 95% CI) was higher among women in the low (259; 245-274ânmol/L) and high (257; 237-276ânmol/L) groups compared with control (184; 169-198ânmol/L; Pâ<â.001); low and high groups did not differ (Pâ=â.83). Similarly, children's baseline-adjusted eTDP was higher in the low (259; 246-271ânmol/L) and high (257; 243-270ânmol/L) groups compared with control (213; 202-224ânmol/L; Pâ<â.001).ConclusionFortified fish sauce appears to be an efficacious means of improving biochemical thiamin status in nonpregnant, nonlactating women and their children (1-5 years of age) living in rural Cambodia.Trial registrationClinicalTrials.gov: NCT02221063.
Journal: The Journal of Pediatrics - Volume 181, February 2017, Pages 242-247.e2