کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5722176 1608108 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research paperAssociation of subjective memory complaint and depressive symptoms with objective cognitive functions in prodromal Alzheimer's disease including pre-mild cognitive impairment
ترجمه فارسی عنوان
انجمن شکایت ذهنی حافظه و علائم افسردگی با توابع شناختی هدفمند در بیماری آلزایمر پیش آگهی شامل اختلال شناختی قبل از خستگی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
چکیده انگلیسی


- Subjective memory complaints are associated with lower objective memory.
- Subjective depressive symptoms are associated with lower psychomotor speed.
- Depression moderated the subjective memory complaints-cognition relationship.
- Self-reports for cognitive decline and depressive symptoms could be informative.

BackgroundSubjective memory complaints (SMC) and depressive symptoms (SDS) are common in the elderly population. However, the relationship among SMC, SDS, and cognitive function remains unclear. We investigated these associations in the elderly from cognitively normal (CN), pre-mild cognitive impairment (MCI), and amnestic MCI (aMCI) groups.MethodsParticipants (CN, 299; pre-MCI, 106; aMCI, 267) underwent comprehensive clinical and neuropsychological assessment. and self-report SMC and SDS questionnaires. SMC and SDS were administered in a self-report format. For each neuropsychological test z-score, stepwise multiple linear regressions were performed to assess the relative contribution of SMC, SDS, and their interactions.ResultsSMC are associated with lower objective memory, while SDS are associated with lower psychomotor speed. Interactions between SMC and SDS were significant for tests of memory, executive function, psychomotor speed, and global cognition. Additional analyses revealed that SDS moderated the SMC-cognition relationship such that only individuals with higher SDS showed significant SMC-cognition associations.LimitationsDue to the cross-sectional design, associations among SMC, SDS, and cognitive function was rather weak, albeit significant. Additionally, future biomarker studies, such as those assessing amyloid burden, are needed to explore the mechanisms underlying the relationship among SMC, SDS, and cognitive function.ConclusionEarly identification of individuals at risk for developing abnormal cognitive changes is critical. Our findings from the study involving a large sample of carefully selected participants suggest that SMC and SDS could be used as early detection markers of Alzheimer's disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 217, 1 August 2017, Pages 24-28
نویسندگان
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