کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5723542 1411455 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The First Case of HER2+ Invasive Ductal Carcinoma Arising From a Breast Hamartoma and Literature Review
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
پیش نمایش صفحه اول مقاله
The First Case of HER2+ Invasive Ductal Carcinoma Arising From a Breast Hamartoma and Literature Review
چکیده انگلیسی
Carcinomas arising from breast hamartomas are exceedingly rare. We present the first reported case of an African-American female presenting with a right breast lump and a subsequent mammogram suggestive of a hamartoma. She later underwent lumpectomy and was found to have HER2+ invasive ductal carcinoma (IDC) arising from a hamartoma. She was amenable to HER2-targeted trastuzumab, hormone therapy and adjuvant radiation but declined chemotherapy. In a review of the literature, IDC is the predominant neoplastic type found in hamartomas. The average hamartoma size at time of neoplasm diagnosis is 6.0 cm. Patients with hamartomas greater than 6.0 cm, with changes in calcification pattern; new nodules or asymmetry should be considered for additional evaluation with ultrasound, MRI and/or biopsy. HER2 status is under-reported among cases and should be evaluated in any malignancy found within hamartomas as HER-2 therapy has improved overall survival and recurrence free survival in HER2+breast cancer patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the National Medical Association - Volume 109, Issue 1, Spring 2017, Pages 55-59
نویسندگان
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