کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5725008 1609439 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The heterogeneity of systemic inflammation in bronchiectasis
ترجمه فارسی عنوان
ناهمگونی التهاب سیستمیک در برونشکتازی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
چکیده انگلیسی


- Patterns of systemic inflammatory protein concentrations in bronchiectasis are heterogeneous.
- Increasing clinical severity of bronchiectasis is associated with increased plasma fibrinogen.
- People with bronchiectasis in the context of CVID are characterised by an exaggerated systemic IL-17 response.

BackgroundSystemic inflammation in bronchiectasis is poorly studied in relation to aetiology and severity. We hypothesized that molecular patterns of inflammation may define particular aetiology and severity groups in bronchiectasis.MethodWe assayed blood concentrations of 31 proteins from 90 bronchiectasis patients (derivation cohort) and conducted PCA to examine relationships between these markers, disease aetiology and severity. Key results were validated in two separate cohorts of 97 and 79 patients from other centres.ResultsThere was significant heterogeneity in protein concentrations across the derivation population. Increasing severity of bronchiectasis (BSI) was associated with increasing fibrinogen (rho = 0.34, p = 0.001 -validated in a second cohort), and higher fibrinogen was associated with worse lung function, Pseudomonas colonisation and impaired health-status. There were generally similar patterns of inflammation in patients with idiopathic and post-infectious disease. However, patients with primary immunodeficiency had exaggerated IL-17 responses, validated in a second cohort (n = 79, immunodeficient 12.82 pg/ml versus idiopathic/post-infectious 4.95 pg/ml, p = 0.001), and thus IL-17 discriminated primary immunodeficiency from other aetiologies (AUC 0.769 (95%CI 0.661-0.877)).ConclusionBronchiectasis is associated with heterogeneity of systemic inflammatory proteins not adequately explained by differences in disease aetiology or severity. More severe disease is associated with enhanced acute-phase responses. Plasma fibrinogen was associated with bronchiectasis severity in two cohorts, Pseudomonas colonisation and health status, and offers potential as a useful biomarker.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Medicine - Volume 127, June 2017, Pages 33-39
نویسندگان
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