کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5732286 1611939 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ResearchMicrobiological aspects of Fournier's gangrene
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Original ResearchMicrobiological aspects of Fournier's gangrene
چکیده انگلیسی


- Treatment of Fournier's gangrene (FG) starts with empirical antibiotic therapy. However, empirical therapy in FG has not been updated in recent years.
- All institutes should evaluate their own culture results and then choose the best empirical antimicrobial therapy regimen.
- Future large studies are necessary to find out the most accurate empirical antibiotherapy for FG.

BackgroundFournier's gangrene (FG) is a devastating disease that is characterized by necrotizing fasciitis of the perineal, genital, or perianal region. Broad-spectrum antibiotics are the key component of its treatment. However, there is paucity of data regarding the optimal empirical antibiotherapy for FG.Materials and methodsData from patients who underwent surgery for FG between January 2007 and December 2012 were retrieved from a prospectively collected departmental FG database. Demographics, clinical characteristics, causative pathogens and drug susceptibility/resistance were evaluated.ResultsFifty patients with a median age of 58.5 (22-83) years were included. The perianal origin (58%) was most commonly affected. A positive growth was found in specimen cultures of 48 (96%) patients. The median number of bacterial strains that grew in the cultures was 3 (0-10). Amikacin was the antibiotic with the highest frequency of sensitivity (74%), while the highest resistance was observed against ampicillin-sulbactam (64%). Escherichia coli was the most common microorganism (72%). Acinetobacter baumannii and Klebsiella pneumonia were significantly more common in patients who required mechanical ventilation. The mortality rate was 26%. An Uludag Fournier's Gangrene Severity Index (UFGSI) score of >9.5 and ventilatory support requirement were factors associated with an increased rate of mortality. Acinetobacter baumannii was the only microorganism which was associated with an increased mortality rate.ConclusionCausative pathogens in FG appeared to be shifting; thus, empirical antibiotic treatment for this disease should be modified. We recommend 3rd-generation cephalosporin, metronidazole and amikacin for empirical therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 40, April 2017, Pages 135-138
نویسندگان
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