Case reportMultidisciplinary management of a patient with van der Woude syndrome: A case report

- We described the orthodontic treatment of a girl diagnosed with VWS.
- Multidisciplinary techniques resulted in satisfactory outcomes.
- Genetic testing determined a known putative splice site mutation.

IntroductionVan der Woude syndrome (VWS) is the most frequent form of syndromic cleft lip and palate (SCLP) accounting for 2% of all patients with CLP.Case presentationWe describe the orthodontic treatment of a girl diagnosed with VWS referred by her family dentist for her cosmetic concerns.DiscussionComprehensive orthodontic treatment, secondary bone graft, distraction osteogenesis (for a deficient maxilla), secondary palatoplasty and excision of lower lip pits, as well as orthodontic and prosthetic procedures may provide a satisfactory outcome. Genetic testing showed a known putative splice site mutation (c.174 + 1 G/A) as the prime cause of VWS in our patient and her family.ConclusionSCLP has significant effects on facial aesthetics and the psychosocial status. Parents should be assessed and counseled appropriately. This condition is treatable in the absence of life threatening systemic anomalies. An interdisciplinary team approach is advocated.