کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735110 | 1612903 | 2017 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Meta-analyses of RELN variants in neuropsychiatric disorders
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کلمات کلیدی
SNPsautistic spectrum disorder - اختلال طیف اوتیستیکattention deficit hyperactivity disorder - اختلال کمتوجّهی _ بیشفعالیBipolar disorders - اختلالات دوقطبیPsychiatric disorders - اختلالات روانیSchizophrenia - اسکیزوفرنی یا شیزوفرنیADHD - بیشفعالیAlzheimer’s disease - بیماری آلزایمرMeta-analysis - فرا تحلیل ASD - نقص سپتوم یا دیوارهی دهلیزیSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Meta-analyses of RELN variants in neuropsychiatric disorders Meta-analyses of RELN variants in neuropsychiatric disorders](/preview/png/5735110.png)
چکیده انگلیسی
Reelin is a critical extracellular matrix glycoprotein and implicated in neurodevelopment and psychiatric disorders in animal model studies. The genetic polymorphism of RELN has also been reported to be associated with several psychiatric disorders, but the results remain controversial. Here, we conducted meta-analyses of RELN gene SNPs and related neuropsychiatric disorders (schizophrenia, autistic spectrum disorders, attention-deficit hyperactivity disorder, Alzheimer's disease and bipolar disorders). A total of 12 SNPs (rs736707, rs362691, rs607755, rs2229864, rs7341475, rs262355, rs362719, rs11496125, g.-888GÂ >Â C, rs2299356, rs528528, and rs4298437) in RELN gene were included into meta-analyses. Subgroup analyses based on ethnicity were performed. We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, ORÂ =Â 1.26, 95% CIÂ =Â 1.13-1.41, PÂ <Â 0.01, FDRÂ <Â 0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, ORÂ =Â 0.88, 95% CIÂ =Â 0.82-0.95, PÂ <Â 0.01, FDRÂ <Â 0.01). No association of other SNPs and psychiatric disorders is found. These findings suggest a role of RELN SNPs in psychiatric diseases, and indicate that further researches in populations with different genetic background and studies with larger sample size are of great value.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 332, 14 August 2017, Pages 110-119
Journal: Behavioural Brain Research - Volume 332, 14 August 2017, Pages 110-119
نویسندگان
Na Chen, Yanping Bao, Yanxue Xue, Yan Sun, Die Hu, Shiqiu Meng, Lin Lu, Jie Shi,