کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735342 | 1612904 | 2017 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long term beneficial effect of neurotrophic factors-secreting mesenchymal stem cells transplantation in the BTBR mouse model of autism
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کلمات کلیدی
MSCTrkBBTBRBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز C57BL/6 - C57BL / 6autism spectrum disorders - اختلالات طیف اوتیسمAutism spectrum disorder - اختلالات طیف اوتیسم گروهیTyrosine kinase B - تیروزین کیناز بRegenerative therapy - درمان داروییMesenchymal stem cells - سلول های بنیادی مزانشیمیNeurotrophic factors - عوامل نوروترفیکBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزAnimal model - مدل حیوانیASD - نقص سپتوم یا دیوارهی دهلیزی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Autism spectrum disorders (ASD) are neurodevelopmental disabilities characterized by severe impairment in social communication skills and restricted, repetitive behaviors. We have previously shown that a single transplantation of mesenchymal stem cells (MSC) into the cerebral lateral ventricles of BTBR autistic-like mice resulted in an improvement across all diagnostic criteria of ASD. We suggested that brain-derived neurotrophic factor (BDNF), a protein which supports the survival and regeneration of neurons secreted by MSC, largely contributed to the beneficial behavioral effect. In this study, we investigated the behavioral effects of transplanted MSC induced to secrete higher amounts of neurotrophic factors (NurOwn®), on various ASD-related behavioral domains using the BTBR mouse model of ASD. We demonstrate that NurOwn® transplantation had significant advantages over MSC transplantation in terms of improving communication skills, one and six months following treatment, as compared to sham-treated BTBR mice. Furthermore, NurOwn® transplantation resulted in reduced stereotypic behavior for as long as six months post treatment, compared to the one month improvement observed in the MSC treated mice. Notably, NurOwn® treatment resulted in improved cognitive flexibility, an improvement that was not observed by MSC treatment. Both MSC and NurOwn® transplantation induced an improvement in social behavior that lasted for six months. In conclusion, the present study demonstrates that a single transplantation of MSC or NurOwn® have long-lasting benefits, while NurOwn® may be superior to MSC treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 331, 28 July 2017, Pages 254-260
Journal: Behavioural Brain Research - Volume 331, 28 July 2017, Pages 254-260
نویسندگان
Nisim Perets, Hadar Segal-Gavish, Yael Gothelf, Ran Barzilay, Yael Barhum, Natalie Abramov, Stav Hertz, Darya Morozov, Michael London, Daniel Offen,