کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5735381 1612902 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine D3 receptor status modulates sexual dimorphism in voluntary wheel running behavior in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Dopamine D3 receptor status modulates sexual dimorphism in voluntary wheel running behavior in mice
چکیده انگلیسی

Sexual dimorphism has been described in various aspects of physiological and pathophysiological processes involving dopaminergic signaling. This might account for the different disease characteristics in men and women in e.g. Parkinson's disease or ADHD. A better understanding might contribute to the future individualization of therapy.We examined spontaneous wheel running activity of male and female mice, homo- and heterozygote for dopamine D3 receptor deficiency (D3R −/− and D3R +/−), and compared them to wild type controls. We found higher wheel running activity in female mice than in their male littermates. D3−/− mice, irrespective of sex, were also hyperactive compared to both D3+/− and wild type animals. Hyperactivity of D3−/− female mice was pronounced during the first days of wheel running but then decreased while their male counterparts continued to be hyperactive. Physical activity was menstrual cycle-dependent. Activity fluctuations were also seen in D3 receptor knockout mice and are therefore presumably independent of D3 receptor activation.Our data underscore the complex interaction of dopaminergic signaling and gonadal hormones that leads to specific running behavior. Furthermore, we detected sex- and D3 receptor status-specific reactions during novel exposure to the running wheel. These findings suggest the need for adapting dopaminergic therapies to individual factors such as sex or even menstrual cycle to optimize therapeutic success.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 333, 30 August 2017, Pages 235-241
نویسندگان
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