کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5735683 | 1612913 | 2017 | 41 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Puberty as a vulnerable period to the effects of immune challenges: Focus on sex differences
ترجمه فارسی عنوان
بلوغ به عنوان یک دوره آسیب پذیر برای اثرات چالش های سیستم ایمنی: تمرکز بر تفاوت های جنسیتی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Puberty is a critical period of development during which sexual maturity is attained. It is also a critical period for brain reorganization and it is vulnerable to exposure to certain environmental factors. Exposure to stress during this period can cause enduring neural and behavioral alterations. More specifically, exposure to an immune challenge during this period can alter reproductive as well as a number of non-reproductive behaviors and can permanently alter the brain's response to gonadal hormones. The present review examines the enduring effect of exposure to LPS and poly(I:C) during the pubertal period. Age and sex differences in acute response to LPS are discussed as possible mechanisms of vulnerability to adverse effects. Moreover, this review suggests new research directions to improve our understanding of the vulnerability of the pubertal period to immunological stressors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 320, 1 March 2017, Pages 374-382
Journal: Behavioural Brain Research - Volume 320, 1 March 2017, Pages 374-382
نویسندگان
Leanne Kane, Nafissa Ismail,